symptoms of a major detoxification? Most of what we hear are rumors and philosophical opinions. As a San Rafael Functional Medicine Doctor, I would like to set the record straight on the subject of detoxification and healing. There is just too much confusion out there and we need to cut through all of the confusion and create some clarity. What is the science behind detoxification? How do you know whether or not the detoxification you are experiencing is healthy or unhealthy? Detoxification signs and symptoms may include skin rash, headaches, nausea, vomiting, diarrhea, fatigue, headaches and a number of other unpleasantries.